Fri Nov 29 2024

30 articles - From Friday Nov 22 2024 to Friday Nov 29 2024

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Pancreas

Peritoneal Tumor DNA as a Prognostic Biomarker in Pancreatic Cancer: A Systematic Review and Meta-Analysis.

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Pancreatology

Meta-analysis of routine abdominal drainage versus no drainage following distal pancreatectomy: Does the best available evidence overcome "HPB surgeon's paranoia"?

The meta-analysis of best available evidence indicates safety of "no drain policy" in distal pancreatectomy considering its lower risk of CR-POPF, re-intervention and hospital re-admission. More randomised evidence is required to overcome the "HPB surgeon's paranoia".

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Cross-sectional associations between consumption of non-nutritive sweeteners and diet quality among U.S. adults in the Cancer Prevention Study-3.

NNS consumers had lower diet quality in a large cohort of U.S. adults.

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Dietary patterns and risk of multiple cancers: umbrella review of meta-analyses of prospective cohort studies.

These findings suggest that adherence to certain healthy dietary patterns is associated with lower risk of al cancers and certain individual cancers. Register This study was registered with PROSPERO (CRD42023425237). crd.york.ac.uk/PROSPERO/display_record.php?RecordID=425237.

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Effect of a 12-month intervention with whey protein powder on cognitive function in older adults with mild cognitive impairment: a randomized controlled trial.

Supplementation with whey protein powder rich in MFGM, taurine, and B vitamins for 12-month improved cognitive function in older adults with MCI.

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Infant body composition trajectories differ by in utero exposure to gestational diabetes mellitus: a prospective cohort from birth to 12 months.

In a cohort of infants exposed and unexposed to GDM in utero, infants exposed had increased weight, FM, and percent body fat at birth. However, more infants exposed to GDM had less fat accrual over the first year of life, compared with those unexposed. The long-term effects of these growth patterns in the first year challenge current concepts and support further investigation of neonatal body composition.

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Maternal vitamin D status, fetal growth patterns, and adverse pregnancy outcomes in a multi-site prospective pregnancy cohort.

First trimester 25(OH)D was positively associated with linear growth. Low first trimester 25(OH)D (<40 nmol/L) was associated with higher risk for preterm birth. Second trimester 25(OH)D was not associated with fetal growth or pregnancy outcomes assessed.

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The effect of an intervention to reduce aflatoxin consumption from 6 to 18 months of age on length-for-age Z-scores in rural Tanzania: a cluster-randomized trial.

and conclusions An intervention to reduce AF exposure did not alter AF-alb nor anthropometric measures between treatment groups. Drought and agricultural data indicated less favorable conditions for toxin production, resulting in low levels of exposure in both trial arms. Annual, seasonal, and geographic heterogeneity of AF contamination make it difficult to study in an ethically-designed trial. Our formative research and early trial data indicate that stunting and intermittent AF exposure continue to be a problem in this area. However, the low AF exposure levels during the trial led to inconclusive results.

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Inflamm Bowel Dis

Glucagon-Like Peptide 1 Receptor Agonists Are Not Associated With an Increased Risk of Ileus or Intestinal Obstruction in Patients with Inflammatory Bowel Disease-A Danish Nationwide Cohort Study.

This study suggests that GLP-1RAs do not increase the risk of ileus or intestinal obstruction in patients with IBD.

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Undetected Dysplasia at Colectomy in Patients With Inflammatory Bowel Diseases. What Are We Missing?

Clinicians should be aware of the risk of missing dysplastic lesions, especially when endoscopic disease activity is moderate/severe, and not only for longstanding disease. Efforts should be made to obtain endoscopic remission to make the "invisible" visible.

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J Crohns Colitis

Development and Validation of a Sexual Quality of Life Score for Youths with Inflammatory Bowel Disease.

BLOOMI score is a new validated score to assess the sexual QoL in 15-25 years with IBD. This tool may improve the screening for sexual challenges encountered by youths with IBD and may support future research into the impact of IBD on young patients' lives.

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Development of an automated tool for the estimation of histological remission in ulcerative colitis using single wavelength endoscopy technology.

By utilizing automated CAD based on non-magnifying SWE for enhanced capillary visibility versus WLE, histological remission was detected with 95.2% diagnostic accuracy in patients with UC, offering stable objectivity and helping to exclude inter-reader variability.

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Knowledge, Values and Preferences regarding Contraceptive Choices among Women living with Inflammatory Bowel Disease.

A quarter of women with IBD were not using any contraception, and long-acting contraceptive use was low. Women prefer effective, easy-to-use contraceptives with minimal side effects but lack knowledge on effective contraception-related issues. Better education and proactive discussions between healthcare providers and patients could improve reproductive health in women with IBD.

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Low Incidence of Macular Edema and Other Ocular Events in the Etrasimod Development Program.

Macular edema and other ocular events were uncommon in patients treated with etrasimod across multiple conditions. Incidence of Macular edema was comparable with placebo.

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Upadacitinib for Induction of Remission in Pediatric Ulcerative Colitis: An International Multi‑center Study.

Upadacitinib is an effective induction therapy for refractory pediatric UC and IBD-U. Efficacy should be weighed against the potential risks of AEs.

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Liver Transpl

Present and future of fecal microbiome transplantation in cirrhosis.

The goal of this review is to highlight the utility of manipulating the gut microbiome with a focus on fecal microbiome transplantation (FMT) in patients with cirrhosis. In addition, we will provide an overview of disease-specific microbial alterations and the resultant impact this has on cirrhosis-related complications.

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The assessment of myopenia and muscle biopsy in pediatric patients with liver disease awaiting liver transplantation - A cross-sectional analysis.

Percent of muscle fibres with centralized nuclei were not different between groups. In conclusion, children with myopenia experience differences in skeletal muscle biological characteristics when compared to children without myopenia at LTx and these findings may have implications for dietary and exercise rehabilitation pre-and post-LTx.

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Pancreas

Enhancing Pancreatic Cancer Therapy with Targeted CD133-Exosome Delivery of PD-L1 siRNA: A Preclinical Investigation.

PD-L1 siRNA-loaded CD133-targeting exosomes demonstrated remarkable anticancer efficacy, characterized by specific binding to CD133-positive pancreatic cancer cells and suppression of PD-L1 expression within these cells.

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Surgical Trends in Chronic Pancreatitis from 2014 Through 2021.

Surgery for benign CP decreased substantially despite the established efficacy of surgical intervention for long-term pain management. The concurrent decline in mortality and rates of pancreatic fistula formation suggest advances over the study years in surgical and postoperative care.

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Pancreatology

Characteristics and prognosis of patients with pancreatic adenocarcinoma not expressing CA19-9: Analysis of the National Cancer Database.

CA 19-9 non-expression is associated with distant metastatic disease at diagnosis and with death in resected non-metastatic patients compared to normal-range CA 19-9 levels. This clinically relevant subgroup requires alternative biomarkers, and may need consideration of more extensive preoperative staging and intensive perioperative systemic therapy.

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Development of a core outcome set for recurrent acute and chronic pancreatitis: Results of a Delphi poll.

Using the OMERACT framework, we developed a core outcome set for RAP and CP. Future research will focus on identifying validated measures for each domain, facilitating standardized assessments across clinical trials.

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Natural history of low-risk branch-duct intraductal papillary mucinous neoplasms and indeterminate pancreatic cysts: Implications on surveillance intervals by cyst size.

Baseline cyst size can be used to guide surveillance intervals for low-risk BD-IPMN/indeterminate pancreatic cysts.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Inflamm Bowel Dis

Is Sarcopenia More Than Just Low Body Mass?

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Inflamm Bowel Dis

Changes in Editorial Leadership.

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Eco-gastroenterology in Inflammatory Bowel Disease Treatment: A Call for Sustainable Healthcare.

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Iron Deficiency Anemia in Patients with Inflammatory Bowel Disease: A Call to Action to Improve Patient Care.

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Potential Utility of Laser Speckle Contrast Imaging to Detect Early Microcirculatory Changes Associated With Erythema Nodosum in Crohn's Disease: A Case Report.

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Liver Transpl

CON: All patients should receive a palliative care consult during LT evaluation.

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PRO: All patients should receive a palliative care consult during LT evaluation.

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Letters&Replies

Letters to the editors and authors’ replies

Inflamm Bowel Dis

Author's Reply: Is Sarcopenia More Than Just Low Body Mass?

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